Chemistry Reference
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6. Kohli RM, Trauger JW, Schwarzer D, Marahiel MA, Walsh CT. Generality of pep-
tide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide
synthetases. Biochemistry 2001;40:7099-7108.
7. Chen H, O'Connor S, Cane DE, Walsh CT. Epothilone biosynthesis: assembly of
the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem. Biol. 2001;8:
899-912.
8. Schracke N, Linne U, Mahlert C, Marahiel MA. Synthesis of linear gramicidin
requires the cooperation of two independent reductases. Biochemistry. 2005;41(44):
8507-8513.
9. Velkov T, Lawen A. Mapping and molecular modeling of S-adenosyl-L-methionine
binding sites in N-methyltransferase domains of the multifunctional polypeptide
cyclosporin synthetase. J. Biol. Chem. 2003;278:1137-1148.
10. Schoenafinger G, Schracke N, Linne U, Marahiel MA. Formylation domain: an essen-
tial modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. J. Am.
Chem. Soc. 2006;128:7406-7407.
11. Hubbard BK, Walsh CT. Vancomycin assembly: nature's way. Angew. Chem. Int.
Ed. Engl. 2003;42:730-765.
12. Luo L, Burkart MD, Stachelhaus T, Walsh CT. Substrate recognition and selection
by the initiation module PheATE of gramicidin S synthetase. J. Am. Chem. Soc.
2001;123:11208-11218.
13. Stachelhaus T, Mootz HD, Marahiel MA. The specificity-conferring code of adeny-
lation domains in nonribosomal peptide synthetases. Chem. Biol. 1999;6:493-505.
14. Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, et al. Confor-
mational switches modulate protein interactions in peptide antibiotic synthetases.
Science. 2006;14(312):273-276.
15. Keating TA, Marshall CG, Walsh CT, Keating AE. The structure of VibH repre-
sents nonribosomal peptide synthetase condensation, cyclization and epimerization
domains. Nat. Struct. Biol. 2002;9:522-526.
16. Bender CL, Alarcon-Chaidez F, Gross DC. Pseudomonas syringae phytotoxins: mode
of action, regulation, and biosynthesis by peptide and polyketide synthetases. Micro-
biol. Mol. Biol. Rev. 1999;63:266-292.
17. Lautru S, Deeth RJ, Bailey LM, Challis GL. Discovery of a new peptide natural prod-
uct by Streptomyces coelicolor genome mining. Nat. Chem. Biol. 2005;1:265-269.
18. Kohli RM, Trauger JW, Schwarzer D, Marahiel MA, Walsh CT. Generality of pep-
tide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide
synthetases. Biochemistry 2001;40:7099-7108.
19. Gehring AM, Mori I, Walsh CT. Reconstitution and characterization of the
Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. Biochemistry
1998;37:2648-2659.
20. Balibar CJ, Vaillancourt FH, Walsh CT. Generation of D amino acid residues in assem-
bly of arthrofactin by dual condensation/epimerization domains. Chem. Biol. 2005;
12:1189-1200.
21. Billich A, Zocher R. N-Methyltransferase function of the multifunctional enzyme
enniatin synthetases. Biochemistry 1987;26:8417-8423.
22. Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT. Identification of a Mycobac-
terium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of
the virulence-conferring siderophore mycobactin. Chem. Biol. 1998;5:631-645.
 
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