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[60] McGovern, S. L., Caselli, E., Grigorieff, N., and Shoichet, B. K. (2002). A Common
mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.
Journal of Medicinal Chemistry 45 , 1712-1722.
[61] Blundell, T. L., and Patel, S. (2004). High-throughput X-ray crystallography for drug
discovery. Current Opinion in Pharmacology 4 , 490-496.
[62] Hartshorn, M. J., Murray, C. W., Cleasby, A., Frederickson, M., Tickle, I. J., and Jhoti, H.
(2005). Fragment-based lead discovery using X-ray crystallography. Journal of Medicinal
Chemistry 48 , 403-413.
[63] Borch, J., and Roepstorff, P. (2004). Screening for enzyme inhibitors by surface plasmon
resonance combined with mass spectrometry. Analytical Chemistry 76 , 5243-5248.
[64] Moy, F. J., Haraki, K., Mobilio, D., Walker, G., Powers, R., Tabei, K., Tong, H., and
Siegel, M. M. (2001). MS/NMR: a structure -based approach for discovering protein ligands
and for drug design by coupling size exclusion chromatography, mass spectrometry and
nuclear magnetic resonance spectroscopy. Analytical Chemistry 73 , 571-581.
[65] Ciulli, A., Williams, G., Smith, A. G., Blundell, T. L., and Abell, C. (2006). Probing hot
spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.
Journal of Medicinal Chemistry 49 , 4992-4500.
[66] Zartler, E. R., Yan, J., Mo, H., Kline, A. D., and Shapiro, M. J. (2003). 1D NMR Methods in
ligand-receptor interactions. Curr Top Med Chem 3 , 25-37.
[67] Zartler, E. R., and Shapiro, M. J. (2006). Protein NMR-based screening in drug discovery.
Current Pharmaceutical Design 12 , 3963-3972.
[68] Neumann, T., Junker, H. D., Schmidt, K., and Sekul, R. (2007). SPR-based fragment
screening: advantages and applications. Current Topics in Medicinal Chemistry 7 , 1630-1642.
[69] Giannetti, A. M., Koch, B. D., and Browner, M. F. (2008). Surface plasmon resonance based
assay for the detection and characterization of promiscuous inhibitors. Journal of Medicinal
Chemistry 51 , 574-580.
[70] Lesuisse, D., Lange, G., Deprez, P., Benard, D., Schoot, b., Delettre, G., Marquette, J.-P.,
Broto, P., Jean-Baptiste, V., Bichet, P., Sarubbi, E., and Mandine, E. (2002). SAR and X-ray.
A new approach combining fragment-based screening and rational drug design: application
to the discovery of nanomolar inhibitors of Src SH2. Journal of Medicinal Chemistry 45 ,
2379-2387.
[71] Congreve, M., Aharony, D., Albert, J., Callaghan, O., Campbell, J., Carr, R. A. E., Chessari,
G., Cowan, S., Edwards, P. D., Frederickson, M., McMenamin, R., Murray, C. W., Patel, S.,
and Wallis, N. (2007). Application of fragment screening by X-ray crystallography to the
discovery of aminopyridines as inhibitors of beta-secretase. Journal of Medicinal Chemistry
50 , 1124-1132.
[72] Jhoti, H., Cleasby, A., Verdonk, M., and Williams, G. (2007). Fragment-based screening using
X-ray crystallography and NMR spectroscopy. Current Opinion in Chemical Biology 11 ,
485-493.
[73] Murray, C. W., Callaghan, O., Chessari, G., Cleasby, A., Congreve, M., Frederickson, M.,
Hartshorn, M. J., McMenamin, R., Patel, S., and Wallis, N. (2007). Application of fragment
screening by X-ray crystallography to beta-secretase. Journal of Medicinal Chemistry 50 ,
1116-1123.
[74] Edwards, P. D., Albert, J. S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O.,
Campbell, J. B., Carr, R. A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R. H. A.,
Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R. C., Murray, C. W.,
Olsson, L. L., Patel, S., Spear, N., and Tian, G. (2007). Application of fragment-based lead
generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar
potency, cellular activity and high ligand efficiency. Journal of Medicinal Chemistry 50 ,
5912-5925.
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