Chemistry Reference
In-Depth Information
Summary Box
The GPI anchor is a glycolipid that can be attached to the C-terminus of a
protein during posttranslational modifi cation. It is composed of a hydrophobic
PI group linked through a carbohydrate containing linker (glucosamine and
mannose glycosidically bound to the inositol residue) to the C- terminal amino
acid of a mature protein. The two fatty acids within the hydrophobic PI group
anchor the protein to the cell membrane. The GPIs are made by preassembling
their components on PI as a scaffold. The synthesis starts on the cytosolic
leafl et of the ER and is completed on the lumenal face of the ER. Inhibitors
affecting different enzymatic steps in the GPI biosynthesis have a great poten-
tial as fungicides and antiparasitic agents.
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