Biomedical Engineering Reference
In-Depth Information
OH
OH
O
OH
HO
OH
15
HO
OH
OH
16
Kumar et al. (
2013
) evaluated the inhibition of biofilm formation in the presence
of zingerone alone and its ability to increase the susceptibility of the pathogen to
ciprofloxacin. SEM of catheter surfaces showed thinner
P. aeruginosa
biofilms in
the presence of zingerone. Further, biofilm was inhibited and eradicated in the
presence of zingerone (structure 17) alone and in combination with ciprofloxacin.
Highly significant inhibition (
p
0.001) was observed when the phytocompound
and antibiotic were used as adjunct therapy. Brandenburg et al. (
2013
) showed that
both the
D
and
L
isoforms of tryptophan inhibited
P. aeruginosa
biofilm formation
on tissue culture plates, with an equimolar ratio of
D
and
L
isoforms producing the
greatest inhibitory effect. Addition of
D
-/
L
-tryptophan to existing biofilms inhibited
further biofilm growth and caused partial biofilm disassembly.
O
H
3
CO
HO
17
In a study conducted by Upadhyay et al. (
2013
), sub-MICS of plant-derived
compounds like cinnamaldehyde (structure 18), carvacrol, thymol (structure 2), and
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