Biomedical Engineering Reference
In-Depth Information
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13
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HO
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14
The antibiofilm abilities of 522 plant extracts against
P. aeruginosa
PA14 was
examined (Cho et al.
2013
). Three species of
Carex
plant extracts inhibited
P. aeruginosa
biofilm formation by more than 80 % without affecting planktonic
cell grow that a concentration of 200
ʼ
g/mL. The most active extract of
Carex
pumila,
the resveratrol dimer
-viniferin (structure 15), was one of the main
antibiofilm compounds effective against
P. aeruginosa
. The compounds
trans
-
resveratrol (structure 16) and
ʵ
-viniferin dose-dependently inhibited the biofilm
formation of two
P. aeruginosa
strains, PAO1 and PA14. Specifically,
trans
-
resveratrol inhibited
P. aeruginosa
PAO1 biofilm formation by 92 % at 50
ʵ
ʼ
g/
mL, and
ʵ
-viniferin inhibited
P. aeruginosa
PA14 biofilm formation by 82 % at
50
-viniferin
inhibited the biofilm formation of enterohemorrhagic
Escherichia coli
O157:H7
by 98 % at 10
ʼ
g/mL without affecting planktonic cell growth. Interestingly,
ʵ
ʼ
g/mL (Cho et al.
2013
).
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