THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS - Modern Tools for the Synthesis of Complex Bioactive Molecules - page 368

FIGURE 11.3 (a) A flow coil; (b) flow coils connected in parallel; (c) flow coils connected in

series.

or in addition, automated sampling techniques can be used to divert aliquots of
reaction media into auxiliary monitoring equipment, allowing LCMS or GCMS to
be assimilated into the system. The Mettler Toledo ReactIR

Flow Cell is one
example of such equipment that can be used to analyze flow streams in real-time,
showing reactive intermediates and the scavenger efficiencies of immobilized
reagents (Figure 11.4) [30].
With these new tools, multistep, convergent synthetic sequences in floware now
possible, conducting multiple individual steps (Scheme 11.13).

FIGURE 11.4 Mettler Toledo ReactIR Flow Cell.