THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS - Modern Tools for the Synthesis of Complex Bioactive Molecules - page 367

(a) Advion NanoTek TM LF; (b) Uniqsis FlowSyn TM ; (c) Vapourtec TM FIGURE 11.2

R2 þ R4.

(H 2 or O 3 ) can also be integrated into flow systems. Flow ozonolysis methods can
also incorporate immobilized reagents as safe workup steps for excess ozone
without contaminating the product [29]. The commercially available ThalesNano
H-Cube generates hydrogen in situ by electrolysis of water and employs cartridges
of immobilized heterogeneous catalysts (including Pd EnCat) to perform hydro-
genations in flow with minimal workup.
Working in flow creates large amounts of data that can be usefully harvested.
For a given reaction, real-time inline analysis can give data on multiple reaction
parameters, which in turn enables rapid optimization, as well as important kinetic
and physical chemical data. Qualitative spectral data can also be acquired using
adjustable wavelength photodiode detectors (or similar spectrometers) that can be
assembled as inline analysis cells. Other diagnostic devices can be used to report on
reaction progress, for example, impedance measurements, Raman spectroscopy,
near or ReactIR, fluorescence measurements, and various bioassays. Alternatively,