Biomedical Engineering Reference
In-Depth Information
TABLE 7.1 Phase-Transfer-Catalyzed Enantioselective Benzylation of Glycine Schiff Base
O
O
catalyst
conditions
Ph
2
C
N
Ph
2
C
N
*
+
PhCH
2
Br
O
t-
Bu
O
t-
Bu
H
Ph
2a
3a
ee (%)
(Configuration)
Catalyst (mol%)
Conditions
Yield (%)
Reference
50% KOH aq, Toluene-CHCl
3
(7:3), 0
C
90
96 (
S
)
8
Br
-
+
H
N
F
F
O
N
F
6a
(10 mol%)
50% KOH aq, Toluene-CHCl
3
(7:3), 0
C
94
95 (
S
)
9
Br
-
+
H
N
O
+
N
N
HO
-
6b
(5 mol%)
50% KOH aq, Toluene-CHCl
3
(7:3), 0
C
93
94 (
S
)
10
2Br
-
+
H
N
+
+
+
Q
F
Q
=
Q
O
N
7a
(5 mol%)
Search WWH ::
Custom Search