Biology Reference
In-Depth Information
Table 2
(continued)
Cytokine
Cell target
End-point
References
IL-6
Mice, rats
Liver ischemia
(
86
)
IL-6
Proliferation of human muscle
satellite cells following acute
muscle damage
(
87
)
IL-6
Mice
Ethanol-induced hepatic steatosis
(
88
)
IL-6
Oligodendrocyte
Differentiation
(
89
)
IL-6
Rat
Diabetic neuropathy
(
90
)
IL-6
Peripheral nerves
Neurotrophic
(
91
)
IL-6
Astrocytes
Oxidative stress
(
92
)
IL-6
Mice
Pulmonary hyperoxic toxicity
(
93
)
IL-6
Organotypic brain culture
Regeneration following lesion
(
94
)
IL-6
Cerebellar granule neurons
NMDA toxicity
(
95
)
IL-6
Mice and vitro
Hyperoxia-induced mitochon-
drial damage
(
96
)
IL-6
Mice
Regeneration of axotomized
hypoglossal nerve
(
97
)
IL-6
Mice
Stroke MCAO
(
98, 99
)
IL-6
Mice
CCl4 hepatotoxicity
(
100
)
IL-6
Mice
Trimethyltin neurotoxicity
(
101
)
IL-6
Mice
Myelination
(
102
)
IL-11
Mice
Acetaminophen hepatotoxicity
(
103
)
LIF
Wobbler mice motor neuron
Neuro-protection
(
104
)
SCF
Tubular epithelial cells,
neurons in vitro
Antiapoptotic
(
105, 106
)
SCF
Mice
Acetaminophen acute liver injury
(
107
)
structural group of the 4-alpha-helical cytokines (
40
), which bind
receptors of the hematopoietic receptor family.
In the case of the IL-6 family of cytokines, all using gp130 as
the signal transduction subunit, it has been proposed to define
them as neuropoietic cytokines (
41
) and, in the paper reporting
CNTF cloning, the authors concluded, from expression patterns,
that its neurotrophic function may be exerted only under patho-
logical conditions (
42
).
Search WWH ::
Custom Search