Biology Reference
In-Depth Information
Table 2
Tissue-protective, neuro-protective, and trophic activities of cytokines in preclinical models
unrelated to hematopoiesis
Cytokine
Cell target
End-point
References
CNTF
Striatal neurons
Excitotoxicity
(
63
)
CT-1
PC12 cells
Apoptosis
(
64
)
CT-1
Rats, mice
Liver ischemia/reperfusion
(
65
)
Flt3L
Rats and primary neurons
Spinal cord injury
(
32, 33
)
G-CSF
Mice
Skeletal muscle regeneration
(
66
)
G-CSF
Stroke and peripheral limb
ischemia
Tissue plasticity
(
67
)
G-CSF
Mice
Myocardial infarction
(
68
)
G-CSF
Cardiomyocyte proliferation
(
69
)
G-CSF
Rat
Muscle proliferation and strength
following skeletal muscle
injury
(
70
)
G-CSF
Rats
Optic nerve crush,
neuroprotection
(
71
)
G-CSF
Mouse, rat
Stroke
(
72, 73
)
GH
Hypoxic-ischemic injury
Neuroprotection
(
74
)
IFN-b
Adult mouse neural progenitor
cells
Decreased apoptosis upon
growth factor withdrawal
(
75
)
IL-10
Primary neurons
Excitotoxicity
(
36
)
IL-3
Septal cholinergic cell line SN6
Neurotrophic
(
76
)
IL-3
Neurons
Amyloid toxicity
(
77
)
IL-3
Gerbil
Cerebral ischemia (CA1 neurons)
(
78
)
IL-3
Spinal motor neuron in rats
Sciatic nerve axotomy-induced
death
(
79
)
IL-3, GM-CSF
Murine sympathetic neurons
Neurotrophic
(
80
)
IL-3, GM-CSF
Rats
Brain lesions
(
81
)
IL-3, GM-CSF,
G-CSF
Central cholinergic neurons
Neurotrophic
(
82
)
IL-6
Mice
LPS-induced TNF production
(
83
)
IL-6
Mice
T cell-mediated liver injury
(
84
)
IL-6
Diabetic rats
Neurovascular function, nerve
perfusion, and vascular
endothelium
(
85
)
(continued)
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