Introduction to New Trends in Cross-Coupling - New Trends in Cross-Coupling: Theory and Applications - page 3

Figure 1.3 Prof. Negishi at Stockholm during the 2010 Nobel Prize ceremony.
Courtesy of Prof. Negishi.

Table 1.1 Growth in the total number of publications and patents on cross-coupling
reactions through April 2014.

Through
2000

Through
2010

Through
April 2014 Pre-1990

Suzuki-Miyaura 20 824 10175 15883

Heck 56 768 4029 5816

Sonogashira 0 156 3623 5689

Stille 3 470 2380 3537

Negishi 0 13 429 737

Buchwald-Hartwig 0 7 253 498

Kumada-Corriu 1 8 136 298

Hiyama 0 1 91 172

Carbonyl a-arylation 13 33 113 193

Thus, Pd-catalyzed cross-coupling reactions comprise one of the most
important classes of synthetic transformations in modern organic
chemistry, providing chemists with an exceptionally powerful tool for the
construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds.
These and many related transformations have become ubiquitous in both
industry and academia. Indeed, as mentioned above, the 2010 Nobel Prize
in Chemistry was a monumental accomplishment

for the assiduous