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Ph
N
Me
NaO
t
-Bu
Ph
N
Me
Ph
t
-Bu
Br
P
rt
Me
Me
NMe
2
96 % Yield
89 % ee
O
Ligand
O
Me
Me
Pd
2
(dba)
3
/Ligand
NaO
t
-Bu
Me
Br
Ph
Me
N
Ph
N
Me
rt
Me
57 % Yield
5 % ee
Figure 2.68 Enantioselective a-arylation of cyclic ketones using a P-stereogenic ligand.
Asymmetric
α
-arylation of oxindoles
(TMEDA)PdMe
2
(4 mol %)
Ligand (4 mol %)
NaO
t
-Bu
R
Me
Me
O
O
cyclohexane, rt - 50 °C
Me
Me
Br
62 - 87 % Yield
54 - 97 % ee
Asymmetric dearomative spirocyclization
Ph
t
-Bu
OH
O
P
Pd(OAc)
2
(4 mol %)
Ligand (12 mol %)
K
2
CO
3
NMe
2
dioxane, 80 °C
99 % Yield
91 % ee
*
Ligand
Br
Figure 2.69 Other Pd-catalyzed asymmetric reactions using a P-stereogenic ligand.
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