Prominent Ligand Types in Modern Cross-Coupling Reactions - New Trends in Cross-Coupling: Theory and Applications - page 70

B(OH) 2
Me P(O)OEt 3

K 3 PO 4

Me

PCy 2

NMe 2

P(O)OEt 3

toluene, 70 °C

KenPhos

93 % Yield
87 % ee

Pd 2 (dba) 3 (5 mol %)
KenPhos (12 mol %)
K 3 PO 4

B(OH) 2
Ph

Br

NO 2

NO 2

Ph

toluene, 70 °C

82 % Yield
72 % ee

Figure 2.66 Pd-catalyzed axially chiral biaryl synthesis using KenPhos.

Br R'

Pd(dba) 2 , KenPhos
LiO t -Bu

R'

R

H

THF, 70 - 100 °C

N

62 - 95 % Yield
66 - 93 % ee

R' = aryl, alkyl

via:

Br

L*Pd R'

R

N

H

B:

Figure 2.67 Pd-catalyzed enantioselective dearomative intramolecular arylation of naphthalenes.