Weight Loss and Adhesion Molecules - Adhesion Molecules - page 222

Table 1 Effects of weight loss and dietary composition on adhesion molecules

Author n Diet Wt loss Ef ect

Clit on et al. 2005 55 Two low-fat diets At er 12 wk sICAM1 Ø by 8%

1) Meal replacements (MR) -6.0 ± 4.2 kg MR with no ef ect of diet composition

or -6.63 ± 3.35 kg C

2) Conventional low-fat diet (C) Mean ± SD

Keogh et al . 2008 70 1) Low carbohydrate, high saturated fat (LC) or At er 8 wk E- and P-selectin Ø by

2) High carbohydrate, low fat (HC) -7.5 ± 2.6 kg LC 32% and 7% respectively

-6.2 ± 2.9 kg HC ICAM-1 Ø15%

Mean ± SD VCAM-1 4%

with no ef ect of diet composition

Keogh et al. 2007 36 1) Low carbohydrate, low saturated fat (LC) or At er 12 wk At er 12 wk

2) High-carbohydrate, low saturated fat (HC) -8.5 ± 4.5 kg LC VCAM-1 Ø 6%

-7.9 ± 5.5 kg HC ICAM-1 Ø 14%

At er 52 wk E-selectin Ø Ø 14%

-4.6 ± 7.6 kg LC At er 52 wk

-4.0 ± 5.8 kg HC sICAM-1 Ø 7% at er 52 wk (P < 0.05)

Mean ± SD E-selectin Ø 10%

P-selectin Ø 15%

with no ef ect of diet composition

Brinkworth et al . 58 1) High protein, moderate carbohydrate (HP) or At er 68 wk sICAM-1 Ø