Adhesion Molecules in Obesity and Metabolic Syndrome - Adhesion Molecules - page 212

Abbreviations

BMI body mass index

CHD coronary heart disease

CVD cardiovascular disease

DBP diastolic blood pressure

HDL high-density lipoprotein

*ICAM-1 intracellular adhesion molecule 1

Ig immunoglobulin

LDL low-density lipoproteins

LPL lipoprotein lipase

MetS metabolic syndrome

NCEP-ATPIII national Cholesterol Education Program Adult Treatment

Panel III

NF-κB nuclear factor-kappaB

OSA obstructive sleep apnoea

PPAR-α peroxisome proliferator-activated receptor-α

SBP systolic blood pressure

T2DM type 2 diabetes mellitus

TLRs toll-like receptors

TNF-α tissue necrosis factor-alpha

*VCAM-1 vascular cell adhesion molecule 1

WHR waist-hip ratio

Key Facts about Obesity and Metabolic Syndrome

1. MetS is the name for a group of risk factors that increase an individual's
chance of developing CHD, CVD, diabetes and stroke.

2. h e diagnosis of MetS is made when an individual has any three out of
the i ve following risk factors: a large waistline, a higher than normal
triglyceride level, a lower than normal level of HDL-cholesterol, a higher
than normal blood pressure and a higher than normal fasting blood
glucose.

3. An adult with a BMI of 30 or higher is considered to be obese.

4. A number of underlying mechanisms have been proposed for the
development of MetS and include insulin resistance and inl ammatory
mechanisms.

* soluble form of adhesion molecules