Biomimetic Interfaces of Plasma- Modified Titanium Alloy - Biomimetic Architectures by Plasma Processing - page 196

the critical factor of cell division and growth. The ion fluence of Ca-
PIII&D strongly affected the spreading of the MG-63 cells on the
surface of titanium. The cell spreading behaviour was associated
with the cell morphology, and the larger Ca fluence enhanced the
network in the fibrillar processes between the cells and toward the
surface of the Ti substrate [33].
Besides calcium, sodium was often used as a PIII&D source to
modify the surface of titanium to achieve biomimetic-bioactive
surfaces favoring cell and tissue growth [35-37]. The surface
bioactivity of titanium after Na PIII&D was evaluated by precipitation
of calcium phosphate and cell culture. As shown in Fig. 6.15, the Na-
PIII&D sample accelerated CaP precipitation on the surface of the

Figure 6.15 Bioactivity of the four samples as determined by calcium

phosphate precipitation from a SBF after 24 h. The calcium
phosphate precipitates are dissolved in HCl and the calcium
concentration in the solution is determined. The values are
scaled to those of the NaOH treated sample as 100%. The labels
indicate Ti (untreated control), Ti-PIII (Na plasma implanted
sample), Ti-II (beam-line implanted sample), and Ti-NaOH
(NaOH treated sample). Reprinted from Ref. [35], Copyright
2005, with permission from Elsevier.