Biology Reference
In-Depth Information
Table 22.1
(continued)
Mouse line
Type of mutation
Major phenotype
Comments
References
Kiss1
tm2 ( cre / EGFP ) Coll
Complete deletion of exon 1 and 2
Hypogonadotrophic
Null mutation
Unpublished
Hypogonadism
Kiss1 expression tagged with CRE-EGFP
fusion protein
Kiss1
tm1.1 ( cre / EGFP ) Stei
Insertion of CRE/EGFP fusion gene
just before exon 1 coding sequence
Males fertile
May retain low level expression of
Kiss1
[
42
]
Females have reduced
fertility
Kiss1
expression tagged with CRE-EGFP
fusion protein
Kiss1
tm1.1 ( cre ) Uboe
Insertion of IRES-CRE just after
Kiss1
coding sequence
Fertile
Neutral mutation
[
43
]
Kiss1
expression tagged with CRE
protein
Lab codes are: Coll (Colledge), Gstn (Gustafson), Rla (Lapatto), Stei (Steiner), On (Organon), Ubeo (Boehm)
AVPV
anteroventral periventricular;
tm
targetted mutation;
Gt
gene trap mutation
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