Effects of Kisspeptin on Hormone Secretion in Humans - Kisspeptin Signaling in Reproductive Biology - page 92

Table 5.2 LH responses to kisspeptin administration
Subjects Isoform Dose and route Results References

Healthy men Kisspeptin-10 0.24 nmol/kg IV ×1 Immediate LH pulse in all men, estimated 17 min

of GnRH secretion induced, resetting of the
GnRH pulse generator

[ 11 ]

Kisspeptin-10 0.0077-2.3 nmol/kg IV ×1 LH increased in a largely dose-dependent fashion,

but a smaller LH response was seen at the
highest dose of kisspeptin (2.3 nmol/kg)

[ 24 ]

Kisspeptin-10 0.3-10 nmol/kg IV ×1 LH increased, with all doses producing a similar

size response

[ 14 ]

Kisspeptin-54 0.125-40 pmol/kg/min IV ×30 min,

then half rate ×60 min (cumulative
dose 0.0075-2.4 nmol/kg)

LH increased in a dose-dependent fashion [ 13 ]

Kisspeptin-10 1.1 nmol/kg/h IV infusion ×8 h LH increased across the course of the study and

became erratic towards the end of the infusion

[ 24 ]

Kisspeptin-10 3.1 nmol/kg/h IV infusion ×22.5 h LH increased across the study and was erratic

through most of the infusion

[ 24 ]

Healthy women Kisspeptin-10 0.24 nmol/kg IV ×1 Kisspeptin strongly induced LH secretion in

preovulatory and mid-luteal women, but
responses in early follicular women were
smaller and less consistent

[ 31 ]

Kisspeptin-10 1-10 nmol/kg IV ×1 Kisspeptin strongly induced LH secretion in

preovulatory women, but little effect was seen
in early to mid-follicular women

[ 14 ]

Kisspeptin-10 2-32 nmol/kg SC ×1 No clear responses to kisspeptin were seen in early

to mid-follicular women

[ 14 ]