Effects of Kisspeptin on Hormone Secretion in Humans - Kisspeptin Signaling in Reproductive Biology - page 93

Table 5.2 (continued)
Subjects Isoform Dose and route Results References

Kisspeptin-10 20-720 pmol/kg/min IV ×30 min, then half

rate ×60 min (cumulative
dose 1.2-43.2 nmol/kg)

No clear responses to kisspeptin were seen in early
to mid-follicular women

[ 14 ]

Kisspeptin-54 1 nmol/kg IV ×1 LH rose gradually across the 3-h study in early to

mid-follicular women

[ 14 ]

Kisspeptin-54 0.2-6.4 nmol/kg SC ×1 LH rose across the study in a biphasic pattern, with

small responses in early to mid-follicular
women, larger responses in mid-luteal women,
and very large responses in preovulatory
women

[ 15 ]

Women
with hypothalamic
amenorrhea

Kisspeptin-54 6.4 nmol/kg SC twice daily ×2 week LH rose after initial exposure to kisspeptin, but this

response decreased over days

[ 43 , 63 ]

Kisspeptin-54 6.4 nmol/kg SC twice weekly ×8 week LH rose after initial exposure to kisspeptin and

continued to respond to kisspeptin (but
decreased partially) across the 8-week study
period; no folliculogenesis or ovulation was
observed

[ 63 ]

Men and women with
mutations in the
neurokinin B pathway

Kisspeptin-10 1.1 nmol/kg/h ×8 h LH pulse amplitude increased [ 45 ]

IV intravenously; SC subcutaneously