Biomedical Engineering Reference
In-Depth Information
Fig. 12.1 Schematic view of gastrointestinal system diseases (excluded liver and endocrine
pancreas) investigated in experimental animal models with stem cell therapy. Approximate
numbers of published papers in relevant journals by June 2011 are indicated in brackets
12.7 Animal Studies Published on Stem Cell Application
for Treatment of Gastrointestinal System Diseases
A schematic representation of the most noteworthy studies published is shown in
Fig.
12.1
.
12.7.1 Esophagus and Stomach
Esophageal replacement: tissue engineering with biomaterials composed of SCs
seeded on biopolymers has been assessed, so far only in in vitro models [
33
].
Gastroesophageal reflux: studies using muscle and BM-MSCs [
34
] injected on
gastroesophageal junction have showed the formation of muscle neofibers with
good results. Nevertheless, recently published articles reveal that BM-SCs could
