Chemistry Reference
In-Depth Information
16. Ahuja S, Crocker E, Eilers M et al (2009) Location of the retinal chromophore in the activated
state of rhodopsin. J Biol Chem 284:10190-10201
17. Ahuja S, Eilers M, Hirshfeld A et al (2009) 6-s-cis Conformation and polar binding pocket of
the retinal chromophore in the photoactivated state of rhodopsin. J Am Chem Soc
131:15160-15169
18. Ahuja S, Hornak V, Yan ECY et al (2009) Helix movement is coupled to displacement of the
second extracellular loop in rhodopsin activation. Nat Struct Mol Biol 16:168-175
19. Ahuja S, Smith SO (2009) Multiple switches in G protein-coupled receptor activation. Trends
Pharmacol Sci 30:494-502
20. Concistr
`
M, Gansmuller A, McLean N et al (2009) Light penetration and photoisomerization
in rhodopsin studied by numerical simulations and double-quantum solid-state NMR spec-
troscopy. J Am Chem Soc 131:6133-6140
21. Gansmuller A, Concistre M, McLean N et al (2009) Towards an interpretation of 13C
chemical shifts in bathorhodopsin, a functional intermediate of a G-protein coupled receptor.
Biochim Biophys Acta 1788:1350-1357
22. Goncalves JA, South K, Ahuja S et al (2010) Highly conserved tyrosine stabilizes the active
state of rhodopsin. Proc Natl Acad Sci USA 107:19861-19866
23. Hornak V, Ahuja S, Eilers M et al (2010) Light activation of rhodopsin: insights from
molecular dynamics simulations guided by solid-state NMR distance restraints. J Mol Biol
396:510-527
24. Bedford L, Lowe J, Dick LR et al (2011) Ubiquitin-like protein conjugation and the
ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov 10:29-46
25. Struts AV, Salgado GFJ, Mart´nez-Mayorga K et al (2011) Retinal dynamics underlie its
switch from inverse agonist to agonist during rhodopsin activation. Nat Struct Mol Biol
18:392-394
26. Ratnala VRP, Kiihne SR, Buda F et al (2007) Solid-state NMR evidence for a protonation
switch in the binding pocket of the H1 receptor upon binding of the agonist histamine. J Am
Chem Soc 129:867-872
27. Cady SD, Schmidt-Rohr K, Wang J et al (2010) Structure of the amantadine binding site of
influenza M2 proton channels in lipid bilayers. Nature 463:689-692
28. Hu F, Luo W, Hong M (2010) Mechanisms of proton conduction and gating in influenza M2
proton channels from solid-state NMR. Science 330:505-508
29. Helmus JJ, Surewicz K, Nadaud PS et al (2008) Molecular conformation and dynamics of the
Y145Stop variant of human prion protein. Proc Natl Acad Sci USA 105:6284-6289
30. Ahmed M, Davis J, Aucoin D et al (2010) Structural conversion of neurotoxic amyloid-[beta]
1-42 oligomers to fibrils. Nat Struct Mol Biol 17:561-567
31. Kawamura I, Ikeda Y, Sudo Y et al (2007) Participation of the surface structure of Pharaonis
phoborhodopsin, ppR and its A149S and A149V mutants, consisting of the C-terminal
alpha-helix and E-F loop, in the complex-formation with the cognate transducer pHtrII, as
revealed by site-directed C-13 solid-state NMR. Photochem Photobiol 83:339-345
32. Saito H, Naito A (2007) NMR studies on fully hydrated membrane proteins, with emphasis
on bacteriorhodopsin as a typical and prototype membrane protein. Biochim Biophys Acta
1768:3145-3161
33. Pfleger N, Lorch M, Woerner AC et al (2008) Characterisation of Schiff base and chromo-
phore in green proteorhodopsin by solid-state NMR. J Biomol NMR 40:15-21
34. Varga K, Aslimovska L, Watts A (2008) Advances towards resonance assignments for
uniformly - C-13, N-15 enriched bacteriorhodopsin at 18.8 T in purple membranes. J Biomol
NMR 41:1-4
35. Bajaj VS, Mak-Jurkauskas ML, Belenky M et al (2009) Functional and shunt states of
bacteriorhodopsin resolved by 250 GHz dynamic nuclear polarization-enhanced solid-state
NMR. Proc Natl Acad Sci USA 106:9244-9249
