Chemistry Reference
In-Depth Information
EFSA.Forthispurpose,aprogramforthereevaluationoffoodadditivesthatwerealreadypermit-
tedintheEUbefore20January2009hasbeensetupunderRegulation(EU)No.257/2010.This
regulationalsoforeseesthatfoodadditivesarereevaluatedwhenevernecessaryinlightofchanging
conditionsofuseandnewscientiicinformation.Inaccordancewiththislegislation,EFSAhasto
reevaluatethesweetenersby31December2020.
14.9 CONCLUDING reMarKS
Allsweetenerspermittedforuseinfoodshavebeensubjectedtoriskassessment.Theuseof
thesweeteners,authorizedasfoodadditivesinfoodproducts,hasbeenregulatedonthebasisof
theADI.Thisregulationhasensuredthattheamountspermittedinfoodsofagivenfoodadditive
would not result in the daily consumption of amounts exceeding the ADI. The consumption of
sweetenersinquantitieswithintheADIdoesnotconstituteahealthhazardtoconsumers.
reFereNCeS
Barlow, S., Pascal, G., Larsen, J.C., and Richold, M.R. 1999. ILSI Europe workshop on the signiicance of
excursionofintakeabovetheacceptabledailyintake(ADI). Regul. Toxicol. Pharmacol. 30:S1-S121.
Barnes,D.,Daston,G.,Evans,J.etal.1995.Benchmarkdoseworkshop:Criteriaofuseofabenchmarkdose
toestimateareferencedose. Regul. Toxicol. Pharmacol. 21:296-306.
Bopp,A.B., Sonders, R.C., and Kesterson, J.W. 1986. Toxicological aspects of cyclamate and cyclohexyl-
amine. Crit. Rev. Toxicol. 16:213-306.
Crump,K.S.1984.Anewmethodfordeterminingallowabledailyintakes. Fundam. Appl. Toxicol. 32:133-153.
EuropeanFoodSafetyAuthority(EFSA).2006a.OpinionoftheScientiicPanelonFoodAdditives,Flavourings,
ProcessingAidsandMaterialsinContactwithFood(AFC)ontherequestfromtheCommissionrelated
tomaltitolsyrupE965(ii)newproductionprocess. EFSA J. 354:1-7.
EuropeanFoodSafetyAuthority(EFSA).2006b.OpinionoftheScientiicPanelonFoodAdditives,Flavourings,
ProcessingAidsandMaterialsinContactwithFood(AFC)ontherequestfromtheCommissionrelated
toanewlong-termcarcinogenicitystudyonaspartame. EFSA J. 356:1-44.
EuropeanFoodSafetyAuthority(EFSA).2007.ScientiicopinionofthePanelonFoodAdditives,Flavourings,
ProcessingAidsandMaterialsinContactwithFood(AFC)ontherequestfromtheEuropeanCommission
onneotameasasweetenerandlavourenhancer. EFSA J. 581:1-43.
EuropeanFoodSafetyAuthority(EFSA).2009a.ScientiicopinionofthePanelonFoodAdditivesandNutrient
SourcesAddedtoFoodonarequestfromtheEuropeanCommissionrelatedtothe2ndERFcarcinoge-
nicitystudyonaspartame. EFSA J. 945:1-18.
EuropeanFoodSafetyAuthority(EFSA).2009b.UpdatedscientiicopinionofthePanelonFoodAdditives
andNutrientSourcesAddedtoFoodonarequestfromtheEuropeanCommissionrelatedtothe2ndERF
carcinogenicity study on aspartame taking into consideration study data submitted by the Ramazzini
FoundationinFebruary2009. EFSA J. 1015:1-18.
EuropeanFoodSafetyAuthority(EFSA).2009c.GuidanceoftheScientiicCommittee:Useofthebenchmark
doseapproachinriskassessment. EFSA J. 1150:1-72.
EuropeanFoodSafetyAuthority(EFSA).2010a.ScientiicopinionofthePanelonFoodAdditivesandNutrient
Sources(ANS)onthesafetyofsteviolglycosidesfortheproposedusesasafoodadditive. EFSA J. 8:
1537[85pp.].
European Food Safety Authority (EFSA). 2010b. Statement of the Panel on Food Additives and Nutrient
Sources(ANS)inrelationtothesafetyoferythritol(E968)inlightofnewdata,includinganewpaedi-
atricstudyonthegastrointestinaltolerabilityoferythritol. EFSA J. 8:1650.[17pp.].
European Food SafetyAuthority (EFSA). 2011. EFSA statement on the scientiic evaluation of two studies
relatedtothesafetyofartiicialsweeteners. EFSA J. 9:2089[16pp.].
Gad,S.C.1990.Recentdevelopmentinreplacing,reducing,andreininganimaluseintoxicologicresearchand
testing. Fundam. Appl. Toxicol. 15:8-16.
Search WWH ::




Custom Search