Biomedical Engineering Reference
In-Depth Information
Fig. 9.18.
Monitoring of a living PaTu8988S cell after adding a toxin (taxol) to the
cell culture medium. Morphological changes such as cell rounding and finally the
cell collapse are induced.
Upper row
: gray level coded unwrapped phase distribution
at
t
=0,
t
= 78, and
t
= 262 min after taxol addition.
Lower row
: Corresponding
pseudo 3D representations of the phase data (Cooperation: Dr. Jurgen Schneken-
burger, Department of Medicine B, University of Munster, Germany) [28]
Fig. 9.19.
Cross sections through the measured optical path length changes cor-
responding to the dashed white lines in the phase distributions of Fig. 9.18 (
up-
per row
) [28]
and
t
= 262 min after taxol addition are depicted. The lower row of Fig. 9.18
shows the pseudo 3D plot of the phase images. Figure 9.19 depicts cross sec-
tions through the measured optical path length changes corresponding to the
dashed lines in the upper row of Fig. 9.18. From Figs. 9.18 and 9.19 it is
clearly visible that the toxin induces morphological changes as cell rounding
and finally the cell collapses.
