Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats - Advances in Experimental Medicine and Biology - page 53

Table 6.7 Serum ALP and osteocalcin concentration of rats fed experimental diets
Variables Control Taurine Signi fi cance

ALP (IU/L) 278.0 ± 45.4 1 260.1 ± 36.4 NS 2

Osteocalcin (ng/ml) 5.7 ± 0.69 3.2 ± 0.09

1 Mean ± SD
2 NS not significantly different at p < 0.05

Table 6.8 PTH of rats fed experimental diets
Variables Control Taurine Signi fi cance

PTH (pg/ml) 15.28 ± 12.10 1 23.42 ± 15.46 NS 2

1 Mean ± SD
2 NS not significantly different at p < 0.05

Table 6.9 Spine BMD and BMC of rats fed experimental diets
Variables Control Taurine Signi fi cance

SBMD (g/cm 2 ) 0.152 ± 0.008 1 0.153 ± 0.009 NS 2

SBMC (g) 0.544 ± 0.050 0.576 ± 0.056 NS

SBMD/wt (kg) 0.38 ± 0.03 0.40 ± 0.02 NS

SBMC/wt (kg) 1.38 ± 0.08 1.51 ± 0.12 NS

1 Mean ± SD
2 NS not significantly different at p < 0.05

osteocalcin were 5.7 ± 0.69 ng/ml in the control group and 3.2 ± 0.09 ng/ml in the
taurine group. No differences were observed in serum ALP and osteocalcin between
the experimental groups.
Serum PTH were 15.28 ± 12.10 pg/ml and 23.42 ± 15.46 pg/ml for the control
and taurine groups, respectively (Table 6.8 ). The concentration of serum PTH was
not significantly different between the experimental groups. Several studies indi-
cated that diurnal variations in serum PTH concentrations influence bone metabo-
lism and that nocturnal increases in PTH secretion favorably affect bone mass
(McKee 1999 ; Chen et al. 2003 ) .

6.3.5 Bone Mineral Density and Bone Mineral Content

The results of spine BMD and spine BMC were shown in Table 6.9 . Supplementation
of taurine to the diet did not affect spine BMD and BMC in comparison with control
group.
Table 6.10 showed the femur BMD and BMC in the experimental male rats.
Femur BMD, BMC, and femur BMD per weight (FBMD/wt) were not significantly
different between experimental groups. However, femur BMC per weight (FBMC/
wt) was significantly higher in the rat-fed taurine-supplemented diet than in the rat-
fed control diet (1.16 ± 0.05 g/wt vs. 1.27 ± 0.10 g/wt).