Biology Reference
In-Depth Information
Table 31.7
Urine deoxypyridinoline, creatinine, and cross-link value of rats fed experimental diets
Variables
Control
Arg
Tau
Arg + Tau
Deoxypyridinoline (nM)
852.6 ± 100.0
1, a, 2
728.4 ± 223.1
a
605.0 ± 175.3
a
621.3 ± 204.3
a
Creatinine (mM)
6.0 ± 0.0
a
6.1 ± 0.4
a
6.0 ± 0.6
a
5.9 ± 0.6
a
Cross-link value (nM/mM) 142.10 ± 16.67
a
121.40 ± 37.19
a
100.44 ± 23.57
a
103.24 ± 30.81
a
1
Mean ± SD
2
Values with different superscripts within the row are significantly different at
p
< 0.05 by Duncan's
multiple range test
socioeconomic burden (Inderjeeth et al.
2012
). The health effects of arginine or tau-
rine have been studied principally in relation to diabetes (Wells et al.
2005
) or anti-
inflammatory effects (Schuller-Levis and Park
2003
). However, no positive effects of
taurine on BMD were found in the ovariectomized rats fed a calcium-deficient diet
(Choi
2009
). Calcium and vitamin D are key nutrients necessary for bone health. In
addition to calcium and vitamin D, vitamin K, magnesium, potassium, and vitamin
C may also play a role in optimizing bone health (Nieves
2005
) . However, most older
children and adolescents in the United States do not meet the adequate intake (AI) for
calcium (Fulgoni et al.
2004
). Clinical trials have shown that calcium supplementa-
tion in children can increase BMD. High protein may exert detrimental effect on
bone density when calcium is low (Heaney
2007
). In light of our interest in the effect
of taurine and arginine on the BMD, we have taken the opportunity to examine the
relation between taurine and arginine supplementation and BMD.
31.3.5
Bone Mineral Density and Bone Mineral Content
BMD and BMC were measured using PIXImus (GE Lunar Co, Wisconsin, USA) in
spine and femur. The data obtained from BMD and BMC of the experimental diets
are shown in Table
31.8
. The spine BMC and BMD were not significantly different
among the experimental groups. Rats fed taurine diet (2.0%) or arginine diet (2.0%)
had no significant difference in spine and femur BMD and BMC than those fed
control diet in female fed an appropriate diet. Supplementation with arginine and
taurine did not significantly alter calcium excretion or markers of bone turnover in
this study. Taurine (2%) was added to the food from 8 to 18 weeks of age. In one
study (Choi
2007a,
b
), arginine supplementation markedly increased BMD in
female rats. This confirms that arginine supplementation increased of bone in female
rats, too. Results of this study are also consistent with the previous study (Choi
2007a,
b
). To our knowledge, the present study was the first attempt to supplement
the amino acids of diet. This study showed that arginine and taurine supplementa-
tion is acceptable to growing female rat with enough calcium. Arginine and taurine
supplementation did not affect urinary calcium excretion. This fining supports ear-
lier studies by us (Choi
2007a,
b
) that taurine or arginine supplementation in diet did
not increase urinary calcium excretion in rats, as long as the amount of calcium in
the diet is enough. Skeletal bone mass reaches over 90% of its maximum by age 18
Search WWH ::
Custom Search