Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 220

Table 6.13

Etoricoxib: regression analysis output, and percent prediction error statistics

Medium/method Power of prediction values* AUC (×10 4 ng h/mL) C max (μg/mL)

r 2 SSE RMSE MAE predicted % PE** predicted % PE**

Solution 0.900 0.193 0.101 0.054 1.943 −6.88 1.007 10.05

FaSSIF-900 mL 0.899 0.195 0.101 0.058 1.942 −6.82 0.989 11.69

0.01 M HCl 0.898 0.197 0.102 0.054 1.941 −6.77 0.990 11.59

USP-SIF 0.676 0.613 0.180 0.093 1.939 −6.66 0.844 24.64

FaSSIF-500 mL 0.593 0.820 0.208 0.114 1.937 −6.55 0.806 28.04

* r 2 - coeffi cient of determination, SSE - sum of squared errors, RMSE - root mean square error, MAE - mean absolute error
** In comparison to the observed values: AUC = 1.818 × 10 4 ng h/mL, C max = 1.12 μg/mL