Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 193

Summary of the CBZ input parameters employed for ACAT model simulation (data from Zhang et al.,
2011)

Table 6.6

Parameter Suspension IR tablet XR tablet XR capsule

Molecular weight (g/mol) 236.3

2.38
12.01 (acidic)
0.26 (basic)
4.3 × 10 −4

log P
pK a

Permeability (cm/s)
Dose (mg) 200 400 400 300

Dose volume (mL)

240

Solubility at pH 6.8 (mg/mL)

0.12 (fasted)
0.32 (fed)
900
9.72 × 10 −4

Precipitation time (s)
Diffusion coeffi cient (cm 2 /s)

Particle density (g/mL) 1.2 1.5 1.2 1.2

Mean particle radius (μm) 5 75 100 50

Particle radius standard deviation 0 20 10 20

Particle radius bin # 1 5 3 3

Body weight (kg) 75 (fasted)

80 (fed)

75 (fasted)
70 (fed)

70 (fasted)
70 (fed)

75 (fasted)
75 (fed)
( Continued )