Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 194

Summary of the CBZ input parameters employed for ACAT model simulation (data from Zhang et al.,
2011) ( continued)

Table 6.6

Parameter Suspension IR tablet XR tablet XR capsule

CL (L/h) 1.127

63.06
44.65
0.309
0.034
0.241

V c (L)
t 1/2 (h)
Lag time, t lag (h)
Distribution rate constant, k 12 (1/h)
Distribution rate constant, k 21 (1/h)
Peripheral volume, V 2 (L) 8.939

Simulation time (h) 168 168 240 192

Dosage form IR suspension IR tablet CR: Integral

tablet

CR:
Dispersed