Biomedical Engineering Reference
In-Depth Information
2.2.3 Thromboresistance ...............................
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2.2.4 Endothelialization................................
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3
cl si s
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References
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Abstract
This review consists of two major parts: recollection of advances in therapeu-
tic cardiovascular biomaterials and a summary of “H-bond grafting” methodology for
biocompatible/biofunctional surface modification of blood-contact polyurethanes. The
development of a H-bond grafting model as depicted in the second part is initiated
with originality that is based on an understanding and rendering of advantages ex-
tracted from the comprehensive investigations reviewed in the first part. The H-bond
grafting strategy is invented via mimicking the buildup of hydrogen bond-based physi-
cal crosslinking points in elastomeric polyurethanes, by which the accordingly designed
surface-modifying additives are anchored to the virtual interface with the favor of a non-
covalent mechanism and the talent of microenvironmental optimization between bioma-
terials and the biological counterparts. This review assembles a series of self-contained
topics covering aspects from prototype setup through various blood-contacting assess-
ments. As a platform of delivery, superior efficacies have been achieved from the H-bond
grafting-modified polyurethane surfaces typically on albumin-selective binding, biocom-
patibility, and engineered endothelialization.
Keywords
Biomaterials
·
Blood compatibility
·
Surface modification
·
Polyurethane
·
Hydrogen bond
·
Endothelialization
·
Protein adsorption
Abbreviations
A adenosine
A(Ala) alanine
AA amino acid
ADP adenosine diphosphate
AT-III anti-thrombine III
ATR-FT-IR attenuated total reflection Fourier transform infrared spectroscopy
BSA
bovine serum albumin
C
cytidine
C18
stearyl, stearic group
C(Cys)
cysteine
N
,
N
-carbonyldiimidazole
CDI
Ciba
triazine dye Cibacron Blue F3G-A
CNBr
cyanogens bromide
D(Asp)
aspartic acid
DCC
dicyclohexyl carbodiimide
E(Glu)
glutamic acid
ECM
extracellular matrix
EC
endothelial cell
EDC
1-ethyl-3-(3-dimethylaminopropyl) carbodiimide
EDRF
endothelial-derived relaxing factor
ePTFE
expanded poly(tetraflouro ethylene)
F(Phe)
phenylalanine
Fg
fibrinogen
