Engineering Blood-Contact Biomaterials by “H-Bond Grafting” Surface Modification - Functional Materials and Biomaterials - page 178

Engineering Blood-Contact Biomaterials
by “H-Bond Grafting” Surface Modification

Dong-An Wang
Division of Bioengineering, School of Chemical & Biomedical Engineering,
Nanyang Technological University, 70, Nanyang Drive, N1.3-B2-13, 637457 Singapore,
Singapore
[e-mail]

This literature is contributed in memory of my beloved advisor,
Professor Lin-Xian Feng of Department of Polymer Science,
Zhejiang University, China

1 Polymeric Biomaterials for Cardiovascular Medical Applications ..... 182

1.1 CardiovascularBiomedicalMaterials ..................... 182

1.1.1 BiomaterialsandCardiovascularApplications ................ 182

1.1.2 CategoriesofCardiovascular-FunctionalPolymers.............. 183

1.1.3 TechnicalParametersofCardiovascularBiomaterials ............ 184

1.2 SurfaceOptimizationandProteinAdsorption ................ 185

1.2.1 ProteinAdsorption ............................... 185

1.2.2 BiologicalRecognitionofCellAdhesion.................... 186

1.2.3 BiomaterialSurfaceConstructionforOptimalProteinBinding ....... 187

1.3 SurfaceThrombogenesisandThromboresistance............... 189

1.3.1 Blood-ImplantInteraction ........................... 189

1.3.2 Anti-ThrombogenicCoating .......................... 190

1.4 Surface-EngineeredEndothelialization .................... 192

1.4.1 FunctionsofEndothelium ........................... 192

1.4.2 EngineeredEndothelializationforArtificialImplants ............ 193

1.5 SurfaceImmobilizationofProteinicAffinityLigands............. 195

1.5.1 SurfaceBioconjugation ............................. 195

1.5.2 SpacerArm ................................... 199

2 “H-Bond Grafting” Surface Modification

for Blood-Contact Polyurethane Biomaterials ................ 200

2.1 “H-Bond Grafting” Surface Modification

forPolyurethaneBiomaterials ......................... 200

2.1.1 ModelMaterialsandSurfaceModifyingAdditives[SMA] .......... 200

2.1.2 SMA “H-Bond Grafting” for Stable Blend
andSurfaceModification............................ 203

2.1.3 SMAMigrationandSurfaceEnrichment ................... 205

2.1.4 SMASurfaceConformationandOptimization ................ 207

2.2 Bio-Functionality of Engineered Polyurethane Surfaces

by“H-BondGrafting”.............................. 210

2.2.1 CoatingApplicationsandInVivoTissueCompatibility ........... 210

2.2.2 SelectiveProteinBinding ............................ 211