Biomedical Engineering Reference
In-Depth Information
Two types of works were carried out: (1) research in
“macromolecular chemistry” with the development of
bioactive
anionic polymer grafting
techniques onto a polymer or metallic
surface and (2) research in “biology” and “translational science” with
the evaluation of the
in vitro
and
in vivo
biological responses of
surfaces grafted with “bioactive” polymers, the validation of the
concept and animal models as well as the applications.
The summary of the works undertaken for prosthesis applications
is split into two parts:
1) concept and feasibility of the grafting of “bioactive” polymers
onto prosthetic surfaces;
2) applications: (a) grafting bioactive polymers onto ligament
prostheses from the LARS society; (b) grafting bioactive polymers
onto total hip prostheses from the Ceraver society.
5.4.2.
Concept and feasibility of the grafting of “bioactive” polymers
onto prosthetic surfaces
5.4.2.1.
Concept
The aim was to develop a covalent grafting technique of
“bioactive” polymers which would be feasible regardless of the
surface of the implant (metallic or polymer), which would be
sufficient (grafting rate) in order to obtain the desired biological
activity, which would resist the sterilization process of medical tools,
and which would be reproducible and applicable on an industrial
scale.
In order to complete these objectives, three surfaces were favored:
- silicone in order to show the feasibility of the covalent grafting of
a bioactive polymer and the creation of an
in vitro
and
in vivo
biological response;
- poly(ethylene terephthalate) (PET) for the development of the
grafting “from” technique and its application in “ligament prostheses”;
