Chemistry Reference
In-Depth Information
TABLE 5.8. Enzymes Reported to Become Inactivated upon Exposure to
Peroxynitrite [248]
Enzyme
Modified Residue
Reference
ATPase
a
Nd
[308]
Succinate dehydrogenase
a
Nd
[308]
Fumarate reductase (
Trypanosoma
cruzi
)
a
Nd
[309]
NAdH: ubiquinone oxidoreductase
a
Nd
[308]
Cytochrome P450 BM-3
b
Cys, Tyr
[256]
Cytochrome P450 2B1
b
Tyr
[310]
Prostacyclin synthase
a,b
Tyr
[311, 312]
Inducible nitric oxide synthase
b
Heme
[313]
glutathione peroxidase
a,b
Selenocysteine
[211, 262, 314, 315]
Alcohol dehydrogenase
b
Zinc sulfur cluster
[231]
Aconitase
a,b
Iron sulfur cluster
[232, 316-318]
6-Phosphogluconate dehydratase
a
Iron sulfur cluster
[316]
Fumarase A
a
Iron sulfur cluster
[316]
Creatine kinase
a,b
Cys
[265]
glyceraldehyde 3-phosphate
dehydrogenase
a,b
Cys
[266, 316]
glutamine synthetase
b
Tyr, Met
[319]
Succinyl-CoA:3-oxoacid CoA
transferase
a
Tyr
[320]
Mn superoxide dismutase
a,b
Tyr
[321]
Cu,Zn superoxide dismutase
b
His B.
[240]
Tyrosine hydroxylase
a,b
Tyr, Cys
[241, 322]
Tryptophan hydroxylase
b
Cys
[323]
Ca2þ-ATPase
a
Cys
[324, 325]
Caspase 3
a,b
Cys
[326]
Protein tyrosine phosphatase
b
Cys
[264]
Nicotinamide nucleotide
transhydrogenase
a
Tyr
[327]
Ribonucleotide reductase
b
Tyr
[328]
Zn
2+
-glycerophosphocolin cholinephos
phodiesterase
b
Tyr
[329]
NAdPH-cytochrome P450 reductase
b
Nd
[330]
glutathione reductase
b
Tyr
[331, 332]
glutathione S-transferase
a,b
Nd
[333]
glutaredoxin
a
Nd
[334]
Protein kinase C
a,b
Tyr
[335]
Ornithine decarboxylase
a,b
Tyr
[336]
xanthine oxidase
b
Molybdenum center
[337, 338]
Lysozyme
b
Trp
[248]
Cystathionine β-synthase (CBS)
Trp, Tyr
[339]
Histone deacetylases
Tyr
[340]
Mitochondrial Lon protease
glutathione
[341]
Paraoxonase-1
Trp
[342]
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