Introduction to Unnatural Foldamers - Metallofoldamers: Supramolecular Architectures from Helicates to Biomimetics - page 79

Figure 2.40 (a) Amido-pyrrole oligomers form an extended supramolecular polymeric chain
in the solid state upon deprotonation of the pyrrolic NH by fluoride. Ref. [91]. Reproduced by
permission of the Royal Society of Chemistry. (b) Anion-bridged self-assembly (top and side
view). Counter cations, Bu 4 N þ and solvents are omitted for clarity. Reprinted with permission
from Ref. [106]. Copyright 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
major aim. Conformational order at this level is important not only as a fundamental
structural goal but also as a prelude to developing foldamers with sophisticated functions,
such as catalysis, which, among proteins, generally require discrete tertiary folding.
Efforts to generate a foldamer tertiary structure have built upon the hierarchical design
strategy put forward by DeGrado and coworkers for the de novo development of
hydrophobic residue
(positively) charged residue
Figure 2.41 Schematic representation of a globally amphiphilic helix and a globally amphi-
philic conformation.