Association of miRNAs with Pathogenesis - Therapeutic Strategies in Cancer Biology and Pathology - page 6

Table 2.1 Pathogenetic Association of miRNAs in Human Disease Table 2.1 (Continued)

Phenotypic Feature Phenotypic Feature MiRNA Identifier MiRNA Identifier Reference Reference

↑Apoptosis, ↓HER2,
EGFR, MAPK
signalling

miRNA-708
↑ miRNA-451 → ↓14-3-3ζ

Saini et al. (2011)
Bergamaschi and
Katzenellenbogen (2012)

Angiogenesis

Inhibition of
angiogenesis

miRNA-221 and miRNA-222
miRNA-221 (?) and c-kit ↓ (?)

Kuehbacher et al. (2008)
Davis et al. (2009)

Promotion of angiogenesis
Upregulated by twist, a
promoter of angiogenesis
VEGF and bFGF regulation;
VEGFR2 and FGFR1

miRNAs-17-92; Let-7f,
miRNA-27b, miRNA-130a

Kuehbacher et al. (2008),
Urbich et al. (2008)
Chamorro-Jorganes et al.
(2011)

miRNA-223
miRNA-16, miRNA-424.

Hypoxia/HIF signalling
↑ P53 → TSP-1 ↓

miRNA-210
miRNA-194

Camps et al. (2008)
Sundaram et al. (2011)

Targeting Metastasis-Associated Genes

Suppressor genes

PDCD4↓ (programmed
cell death 4) protein,
PTEN

miRNA-21 Asangani et al. (2008),

Frankel et al. (2008), Yang
et al. (2011a), Li et al.
(2010e)

Maspin ↓ miRNA-21 Zhu S et al. (2008)

CADM1 Zhu S et al. (2008)

EPB41L3 miRNA-223 Li et al. (2011c)

RECK ↓ (reversion-
inducing-cysteine-rich
protein with Kazal motifs)

miRNA-21 ↑ Wu et al. (2011c), Reis et al.

(2012)

Radiosensitivity/Drug Resistance
let-7 and miRNA-200 miRNA-
214, 130a, miRNA-27a, 451,
↑ miRNAs, P-glycoprotein ↑

van Jaarsveld et al. (2010)
Li et al. (2010g)

Lin28-let7a Oh et al. (2010)

Topotecan and
irinotecan sensitivity

MiRNA-24
MiRNA-21

Gmeiner et al. (2010)
Misawa et al. (2010)

Note : ↑ indicates miRNAs upregulated expression; downregulation in tumours ↓ is given under tumour suppressors
because loss or reduced expression suggests suppressor function.

In gastric cancers GLO1 overexpression correlated with invasion of the gastric wall
and nodal metastasis. Significantly, overexpression was inversely related to patient
survival (Cheng et al., 2012c). The enhanced GLO1 expression appears to be due
to amplification of the GLO1 gene (Santarius et al., 2010). GLO1 has also been