Association of miRNAs with Pathogenesis - Therapeutic Strategies in Cancer Biology and Pathology - page 5

Table 2.1 Pathogenetic Association of miRNAs in Human Disease Table 2.1 (Continued)

Phenotypic Feature Phenotypic Feature MiRNA Identifier MiRNA Identifier Reference Reference

Growth suppression
targets MUC4

miRNA-150 Dugas et al. (2010)

Srivastava et al. (2011)

Tumour Suppression
Tumour suppression
in vivo models
+ ↓Suvivin and ↑ apoptosis

miRNA-34a Tivnan et al. (2011)

Let-7f Liang et al. (2011b)

miRNA-708 Saini et al. (2011)

↓ Breast cancer miRNA-125b

miRNA-183

Zhang et al. (2011b)

↓ NSCLC miRNA-200c Ceppi et al. (2010)

↓ Liver cancer miRNA-122 Tsai et al. (2009)

↓ Pancreatic cancer miRNA-132 Zhang et al. (2011a)

↓ Astrocytomas
grades III and IV

miRNA-124 miRNA-137 Silber et al. (2008)

↓ Oro/pharyngeal
carcinoma

miRNA-9 Minor et al. (2012)

↓ Oral squamous
cell cancers

miRNA-218, miRNA-585 Uesugi et al. (2011)

↓ Oesophageal cancer miRNA-145, miRNA-133a

and miRNA-133b

Kano et al. (2010)

↓ Colorectal cancer miRNA-345 Tang et al. (2011a)

↓ Prostate cancer miRNA-145 Suh et al. (2011)

↓ Endometrial cancer cells miRNA-152 Tsuruta et al. (2011)

↓ Acute myeloid leukaemia,
acute lymphoblastic,
chronic lymphocytic,
chronic myeloid, non-
Hodgkin's lymphoma

miRNA-193a
miRNA-124-1

Gao et al. (2011)
Wong et al. (2011)

↓ Liposarcomas
↓ Gastric cancer

Let-7 Finoux and Chartrand (2008)

Let-7b, Let-7g Bianchini et al. (2011)

Let-7a, Let-7f Li et al. (2011c)

Liang et al. (2011b)

EMT inhibition Let-7d Chang et al. (2011a)

miRNA-34c Yu et al. (2012a)

miRNA-200s Zhang et al. (2012f)

Via upregulation by p53
Via downregulation
of BMI-1

miRNA-200c
miRNA-194

Chang et al. (2011b)
Dong et al. (2011)

Induction of apoptosis miRNA-34a Tarasov et al. (2007)

Cell cycle arrest in G1 miRNA-34a

Upregulation by p53 miRNA-34a

Induction of apoptosis
via p21 inhibition

miRNA-101 Semaan et al. (2011)

Induction apoptosis
via Akt targeting
↓ Survivin + ↑ apoptosis

miRNA-184 Foley et al. (2010)