Biomedical Engineering Reference
In-Depth Information
approaches based on surfactants and difunctional crosslinking agents can affect the
structure, GAG content, biocompatibility and calcification potential of these tissues. Because
of this, different postreatment methods have been suggested showing some improvements
but until today, the vascular graft or heart valve obtained do not fulfill all the requirements
for a long term use. In addition to this safety concerns, these treatments are not yet cost
effective. Therefore, methods that preserve simultaneously the mechanical properties of
collagen and the properties of the GAG matrix are desirable. Finally, those approaches that
made use of enzymatic methods and low toxicity chemical such natural products and
aminoacids as crosslinking agents seem promising alternatives.
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