Biomedical Engineering Reference
In-Depth Information
Crosslinking agent
Collagen
Masking
Crosslinking
Intramolecular
crosslinks
Short range
intermolecular
crosslinks
Large range
intermolecular
crosslinks
Table 6. Schematic representation of presumable masking and intra- or inter-molecular
crosslinking structures
rates. Also it was reported the effectiveness of EDAC and neomycin (an inhibitor of the
enzyme hyaluronidase) for the prevention of glycosaminoglycans loss (Ragharan et al., 2007;
Shah & Vyavahare, 2008). The addition of exogenous glycosaminoglycans and the
stabilization of endogenous glycosaminoglycans in ostrich perichardium reduced tissue
calcification after implantation in rats, but slightly increased the presence of matrix-
metalloproteinase at the implantation site (Arenaz et al., 2004).
5. Conclusions
Natural tissues from various sources can be used as biomaterials in the cardiovascular field
after decellularization and fixation with various crosslinking agents. However, the current
