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(a)
(c)
(e)
(g)
100 m
100 m
100 m
100 m
(b)
(d)
(f)
(h)
50 m
50 m
50 m
50 m
Figure 4.11 Representative cryo-TEM micrographs of different nonlamellar lipid nanoparticles. Panels (a), (b), (c), and (d): Reversed
bicontinuous cubic phase particles viewed along [001] [(a) and (b)] and [111] [(c) and (d)] directions. Panels (e) and (f): Monodisperse
“sponge” phase nanoparticles. Panels (g) and (h): Reversed hexagonal monocrystalline particles. Fourier transforms of magnifi ed areas in
panels (b), (d), (f), and (h) show the structural periodicity of the different nanoparticles consistent with the mesophase structures indicated
above (Barauskas et al., 2005).
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