Chemistry Reference
In-Depth Information
100
110
111
200
211
220
221
220
311
Cubosomes
Pn3m
10
100
110
200
Hexosomes
222
422 333
H
2
q
max
Micellar cubosomes
1
Fd3m
Emulsified microemulsion
Emulsion
0.1
0
1
2
3
q [nm
-1
]
80
70
Emulsified
microemulsion
60
Hexosomes
50
Micellar
cubosomes
40
30
20
Cubosomes
10
0
50
60
70
δ
value (MLO content)
80
90
100
Figure 4.10
SAXS data and a putative “phase diagram” showing LLC phases found
within aqueous monolinolinein (MLO) dispersions as a function of % MLO relative
to decane (Moitzi et al., 2007).
Cryo - TEM image analysis often fi nds that cubosomes are observed in
coexistence with vesicles or vesiclelike structures (Fig. 4.11a). Hexosomes
show two morphologies: one comprising faceted rigid particles as shown in
Figure 4.11 and others exhibiting curved striations (Sagalowicz et al., 2006a).
Spicer and Hayden (2001) also employed cryo-TEM extensively in developing
a low-energy dilution approach to cubosome manufacture.
4.3.2.2 Tilt-Angle Cryo-TEM
In conventional cryo-TEM imaging as de-
scribed above, crystallographic analysis (e.g., confi rmation of three-dimensional
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