Mechanical Stretching and Signaling Pathways in Adipogenesis - The Mechanobiology of Obesity and Related Diseases - page 50

Table 1 (continued)
Conditions

Cell Mechanotransduciton Effect on

adipogenesis
(or cell fate)

Refs

Axis Motion Strength Duration Name Character Signal Downstream

Hydrostatic
pressure

Cyclic 120/80 mmHg

1Hz

1 or 3 days MSC (rat) MSC uncertain uncertain (endothelial) [ 31 ]

20 dynes/cm 2 Shear

stress (flow)

Laminar 1 or 3 days MSC (rat) MSC uncertain uncertain (endothelial) [ 31 ]

ASC adipose stem cells, MSC mesenchymal stem cells, HUCPVC human umbilical cord perivascular cells, SGBSC Simpson-Golabi-Behmel syndrome, ERK
extracellular signal regulated protein kinase, COX cyclooxygenase, TIPs tension induced/inhibited proteins, MAPK mitogen activated protein kinase, PPAR perox-
isome proliferator-activated receptor, RhoK Rho-kinase, Runx Runt-related transcription factor, SRF serum reponse factor, Pref-1 preadipocyte factor 1, Wnt wingless
related MMTV integration site, C/EBP CCAAT-enhancer binding protein, KLF Krüppel-like factor, MyoD myoblast determination factor, AJ18 synonym of Zfp353c,
zinc finger protein 353c, Msx2 Msh homeobox gene family, Dlx5 Distal-less homeobox family, Sox sex determination region-Y box