Biomedical Engineering Reference
In-Depth Information
Table 1 (continued)
Conditions
Cell
Mechanotransduciton
Effect on
adipogenesis
(or cell fate)
Refs
Axis
Motion
Strength
Duration
Name
Character
Signal
Downstream
Uni-axial
Static
105%
4—16 h
Embryonic
lung (mouse)
MSC
TIP-1 :
PPARc2 ;
Inhibition
[
133
]
TIP-3 ;
SRF :
105%
6 h
3T3-L1 (mouse)
preadipocyte
TIP-1:
PPARc2 ;
Inhibition
[
134
]
TIP-3;
TIP-6;
SRF :
Multi-/
equibi-axial
Static
120%
3 days
Differentiated
3T3-L1 (mouse)
adipocyte
Rho—RhoK : uncertain
Hypertrophy
[
35
]
Micro-
patterning
7 days
hMSC (human)
MSC
Rho—RhoK : uncertain
Inhibition
[
76
]
106—112 %
18—25 days
3T3-L1 (mouse)
preadipocyte
ERK :
uncertain
Stimulation
[
36
-
38
]
Compressive
force
Static
226 Pa
12 h
SGBSC (human)
preadipocyte
WntlOB :
PPARc2 ;
Inhibition
[
39
]
COX-2 :
C/EBPa ;
Pref-1 :
KLF2 :
0.5 g/cm
2
(49 Pa)
Compressive
force
C2C12 (mouse)
MSC
p38MAPK:
PPARc ;
Stimulation
[
41
]
MyoD ;
AJ18;
Runx2 :
Msx2 :
Dlx5 :
Osterix :
Sox5 :
Sox9 :
Compressive
force
Cyclic
2000 le
1Hz
2 or 6 h
ASC (mouse)
MSC
uncertain
PPARc ;
Stimulation
[
40
]
(continued)
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