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and enabling single neuron physiology and biochemistry. Combining the
advantages of being able to examine the electrophysiology and
biochemistry of single neurons with the opportunities to silence selected
gene transcripts using RNAi would provide a powerful platform for
parasite gene function studies at the single cell level. Exploiting these
unique opportunities will ensure that Ascaris continues to inform basic
neurobiology and parasite control.
Acknowledgments
The authors would like to thank Philippa Claude for critical reading of the chapter and Bill
Feeny for help with the illustrations. AOWS acknowledges support from US Public Health
Service grant RO1-AI15429, National Science Foundation grant IOS1145721, and a John
Bascom Professorship from the University of Wisconsin-Madison. AGM acknowledges
support from the Biotechnology and Biological Sciences Research Council, Merial, and the
Department of Agriculture and Rural Development for Northern Ireland.
References
1. Hesse R. Uber das Nervensystem von Ascaris lumbricoides und Ascaris megalocephala.
Z Wiss Zool Abt A 1892;90:73
136.
2. Goldschmidt R. Das Nervensystem von Ascaris lumbricoides und Megalocephala. Ein
versuch, in den aufbau eines einfachen nervensystems einzudringen, Zweiter Teil.
Z Wiss Zool Abt A 1908;90:73
e
136.
3. White JG, Southgate E, Thomson JN, et al. The structure of the ventral nerve cord of
Caenorhabditis elegans. Philos Trans R Soc Lond B Biol Sci 1976;275(938):327
e
48.
4. White JG, Southgate E, Thomson JN, et al. The structure of the nervous system of the
nematode Caenorhabditis elegans. Philos Trans R Soc Lond B Biol Sci 1986;314(1165):1
e
340.
5. Del Castillo J, De Mello WC, Morales T. Inhibitory action of gamma-aminobutyric acid
(GABA) on Ascaris muscle. Experientia 1964;20(3):141
e
3.
6. Del Castillo J, De Mello WC, Morales T. The initiation of action potentials in the
somatic musculature of Ascaris lumbricoides. J Expl Biol 1967;46(2):263
e
79.
7. Chitwood BG, Chitwood MB. Introduction to Nematology. University Park Press; 1974.
8. Stretton AO, Fishpool RM, Southgate E, et al. Structure and physiological activity of
the motoneurons of the nematode Ascaris. Proc Natl Acad Sci USA 1978;75(7):3493
e
7.
9. Angstadt JD, Donmoyer JE, Stretton AO. Retrovesicular ganglion of the nematode
Ascaris. J Comp Neurol 1989;284(3):374
e
88.
10. Vanfleteren JR, Van de Peer Y, Blaxter ML, et al. Molecular genealogy of some nema-
tode taxa as based on cytochrome c and globin amino acid sequences. Mol Phylogenet
Evol 1994;3(2):92
e
101.
11. Nanda JC, Stretton AOW. In situ hybridization of neuropeptide-encoding transcripts
afp-1, afp-3, and afp-4 in neurons of the nematode Ascaris suum. J Comp Neurol 2010;
518:896
e
910.
12. Geary TG, Klein RD, Vanover L, et al. The nervous systems of helminths as targets for
drugs. J Parasitol 1992;78(2):215
e
30.
13. Martin RJ. Neuromuscular transmission in nematode parasites and antinematodal
drug action. Pharmacol Ther 1993;58(1):13
e
50.
14. Martin RJ. Modes of action of anthelmintic drugs. Ve t J 1997;154(1):11
e
34.
e
