Genetics of Domesticated Behavior in Dogs and Foxes - Genetics and the Behavior of Domestic Animals - page 381

Vvu12

cM

Mb

FH2019 0.0

54.4
45.0
37.6
33.1
30.5
27.3
17.6
15.1
14.2
13.3
9.1
7.3

FH2019

FH3393
REN245N06
CM11.33
CM11.27
CM11.15
CM11.13
FH4031
REN242K04
REN94K23
REN282122
AHT137
REN01G01
CM35.7a
CM35.4a
CM5.34
CM5.41
CM5.60
CM5.63
FH3928
FH3004
FH3320
ZUBECA6
REN285123
FH3702
DTR05.8
CM5.41b
FH3278
CPH18
CM5.627
REN175P10
REN05DD5
CM5.781
FH3089
CM5.832
CM5.894 104.4

4.9

Cfa11

FH3393

10.2 REN245N06

FH2004

CM11.33

13.0

FH2004

15.7

CM11.27

18.5 REN242K04

CM11.7a
REN112C08

CM11.15

19.2

FH4D31

20.0

CM11.13

20.0 AHT13.7

21.3

CM11.7a

REN172L08
CM35.13d
CM35.11b
CM35.9a
REN214H22

21.3

28.8
25.9
23.5
22.5
18.8
14.1
13.1
11.8
9.7
9.0
4.3

REN1122C08

22.2

REN172LOB

23.0

REN94K23

23.9

REN214H22

Cfa35

REN262122

24.8

REN01G01

27.2

CM35.13d

CM5.37

CM35.11b

28.4

CM35.9a

30.3 CM35.7a

CM35.4a

31.1

36.9

3.4
3.7
4.1
6.0
6.3
9.4
14.9
16.8
22.7
25.2
32.9
40.4
40.9
53.6
53.6
54.5
55.2
62.0
62.7
68.4
70.1
71.4
76.1
76.9
80.5
83.2
89.4

CM5.34

42.7

CM5.37

45.2

CM5.41

CM5.60

49.6

CM5.63

51.7 FH3928

53.7

FH3004

Cfa5

FH3320

56.5

ZUBECA6

REN285123

57.5

FH3702

FH3978

64.8

DTR05.8

65.5

CMS.41b

FH3978

C05.771

74.0

FH3278

78.2

CPH18

CO5.771

CM5.701 84.9

REN175P10

89.9

CM5.627

REN05D05

C05.377 93.0

CMS.701

95.8

C05.377

CM5.761

TAT FH3089

TAT

CM5.832

CM5.894

FIGURE 10.5 A locus for the first principal component of behavior (PC1) on Fox chromosome
12 (VVU12). The meiotic linkage map of VVU12 (left side of figure) is aligned to the genome
sequence of the homologous canine chromosomes (CFA11, CFA35, CFA5) on the right side of the
figure (data and map distances from Kukekova et al., 2011). In the middle of the figure, the gray
interval indicates the broad support interval for PC1 in the silver fox, and the black interval a region
homologous to a locus on CFA 5 identified with domestication of the wolf ( VonHoldt et al.,2010 ).

mapping will help to identify genes under selection for behavior.
Transcriptome sequencing of brain samples from tame and aggressive foxes
has recently been initiated ( Kukekova et al., 2011b ). Although only prelimi-
nary results have so far been reported, this has provided significantly
expanded genomic resources for the fox, a species without a sequenced
genome; as well as significant insights into the gene expression profile of the
fox prefrontal cortex, expression differences between fox samples, and a
catalog of potentially important gene-specific sequence variants ( Kukekova
et al., 2011b ). This approach can provide valuable insights into the molecular
mechanisms implicated in behavioral differences between the two strains.

WHAT THE FARM-FOX EXPERIMENT TELLS US
ABOUT BEHAVIOR
One of the most striking results of the farm-fox experiment is the clear dem-
onstration of the influence of genes on behavior ( Kukekova et al., 2008,
2011a; Trut, 1980a, b, 2001 ).