New Trends in Polymers - Progress in Organic and Physical Chemistry: Structures and Mechanisms - page 201

TABLE 2 (Continued)

Type of device Thickness/

diameter,
—m

Animal Site of implantation/

surgical procedure

Relative
mass loss
of PHB,
%

Relative
loss of PHB
molecular
weight, %

Time,
months

Links

thin films
and ground
particles

- rabbit subcutaneously and

intramuscularly in
the legs

>30* - 2 59

nonwoven
patch
(consisted of
fibers)

200-600
(of patch)
2-20 (of
fibers)

sheep on the wall of

pericardium to close
artificial defect and
prevent pericardial
adhesions

>90* - 24 55

nonwoven
patch
(consisted of
fibers)

200-600
(of patch)
2-20 (of
fibers)

sheep as transannular

patches on the wall
of right ventricular
outflow tract and
pulmonary artery

>99* - 12 56

nonwoven
patch (con-
sisted of fibers)

200-600
(of patch)
2-20 (of
fibers)

calve on the septal of right

atrium to close artifi-
cial septal defect

>99* - 12 53

nonwoven
patch (con-
sisted of fibers)

200-600
(of patch)
2-20 (of
fibers)

patient on the wall of

pericardium to close
artificial defect and
prevent pericardial
adhesions

27 - 24 57

microspheres 0.5-0.8 rat intravenously 8* - 2 19

microspheres 100-300 mice intramuscularly in

the legs

0* - 2 58

Rivet shaped
plate

2300 rabbit intraosseously, into

the lateral condyle of
femur

<10* - 6 37

* Indirect data

16.3 APPLICATION OF PHB
16.3.1 Medical Devices on the Base of PHB and PHB in vivo
Biocompatibility
The perspective area of PHB application is development of implanted medical devices
for dental, craniomaxillofacial, orthopedic, cardiovascular, hernioplastic, and skin sur-
gery. A number of potential medical devices on the bases of PHB: bioresorbable sur-
gical sutures [17, 18, 62, 63], biodegradable screws and plates for cartilage and bone
fixation [24, 52], biodegradable membranes for periodontal treatment, surgical meshes
with PHB coating for hernioplastic surgery [24], wound coverings [64], patches for