Chemistry Reference
In-Depth Information
TABLE 2
Biodegradation of PHB
in vivo
(data for comparison).
Type of device
Thickness/
diameter,
m
Animal
Site of implantation/
surgical procedure
Relative
mass loss
of PHB,
%
Relative
loss of PHB
molecular
weight, %
Time,
months
Links
film (injection
molded)
1200
mouse
subcutaneously
1.6
43
6
13
film (solvent
casting)
150-200
rabbit
subcutaneously
(dorsal side)
6
60
6
10
film (solvent
casting)
50
rat
subcutaneously
(ventral side)
100
100
3
24,25
porous PHB/
atactic PHB
patch
100
rat
intraperitoneally to
repair a bowel defect
>90*
62
6.5
11
porous PHB/
atactic PHB
patch
250
minipigs
with contact to bone
and dura mater to
cover rhinobasal skull
defects
>50*
65
6.5
12
Films and
plates
100-1000
rabbit
subperiostally on
the osseus skull or
respectively on cut
trough zygomatic
arches
100
-
25
52
Films and
plates
100 and
500
rabbit
subperiostally on
the osseus skull or
respectively on cut
trough zygomatic
arches
<10*
-
20
52
Plates and
screws
500 and
1500
rabbit
subperiostally on
the osseus skull or
respectively trough
osseus skull
0
-
12
25
cylinder (nerve
conduits)
150 (of
wall)
rat
nerve wraparound to
bridge an irreducible
nerve gap
0
-
1
16
cylinder (nerve
conduits)
150 (of
wall)
cat
nerve wraparound to
bridge an irreducible
nerve gap
>25*
-
12
15
monofila-ment
suture
-
rat
subcutaneously
(dorsal side)
0
-
6
17
monofila-ment
suture
30
rat
subcutaneously
(fold of neck)
30
-
6
18
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