Structural State of Erythrocyte Membranes from Human with Alzheimer’s Disease - Progress in Organic and Physical Chemistry: Structures and Mechanisms - page 109

a result of increased membranes lability (~twice above normal) membranes mesomor-
phic structure is altering insomuch rapidly, that both the lasting and recent memory
are lost.
FIGURE 1 Relative changes of the erythrocyte membrane microviscosity. Control parameters
(K) of W ɫ : 1.10*10 -10 s for probe I (left side) 1.92*10 -10 s for probe II (right side)
Changes of LPO parameters are shown in Table 1. Mechanical hemolysis (MH)
was increased for the ¿ rst, second, and third patients. Erythrolysis were further grow-
ing during incubation period. At the same time MDA content were enhanced before
incubation. These facts speak about enhanced LPO rate [14]. The MH were within
normal limits for fourth patient, but extremely high after incubation. As for MDA
content it was much higher than control before and after, incubation. Such parameters
are speci¿ c for the stress situations [14]. In this case LPO rate were also increased.
Both hemolysis and MDA content were deeply decreased before incubation for
the ¿ fth, sixth, and seventh patients, with no growth of the hemolysis during incuba-
tion period. For all three patients MDA/PH relation were signi¿ cantly increased. That
means LPO rate suppressed because of substrate depletion. Such continuous that LPO
rate decreasing can leads to remolding and disorganization of the membrane structure,
enhancing percentage composition of phospholipids, disposed to reoxidation, and de-
struction of the cell due to lack of lipids. Perhaps, at this stage of the AD development
organism tries to save erythrocytes from further lysis, which can lead to concentration
of the unsaturated lipids in the membranes.
Hemolysis and MDA content were decreasing during incubation period for the
eighth, ninth, and tenth patients. This fact indicates a substrate depletion and consequently,