Biomedical Engineering Reference
In-Depth Information
Table 2.5
Structural characteristics of known lasso peptides and
their truncated forms
Peptide
Peptide
length (aa)
Peptide net
charge
a
Method for
analysis of 3D
structure
Ring size
(aa (Nb of
atoms))
Ring forming
residue
Lasso stabilization
plugs
b
C-terminal
tail
size (aa)
References
Actinobacteria
Aborycin
RP 71955
21
1−
NMR
9 (25)
Asp9
2 S-S bridges
Cys1-Cys13
Cys7-Cys19
12
(Frechet et al.
1994
; Pot-
terat et al.
1994
)
Siamycin I/
MS-271/NP-06/
Siamycin II
21
21
1−
1−
NMR
NMR
9 (25)
9 (25)
Asp9
Asp9
2 S-S bridges
Cys1-Cys13
Cys7-Cys19
2 S-S bridges
Cys1-Cys13
Cys7-Cys19
12
12
(Constantine et al.
1995
)
(Katahira et al.
1996
; Yano
et al.
1996
)
Sviceucin/
SSV-2083
20
2−
NMR
9 (25)
Asp9
Two S-S bridges
Cys1-Cys13
Cys7-Cys19/
Trp17
11
(Ducasse et al.
2012a
)
(Kersten et al.
2011
)
Anantin
17
0
N.E.
8 (26)
Glu8
n.i.
9
(Weber et al.
1991
; Wyss
et al.
1991
)
Lariatin A
c
Lariatin B
18
20
2+
2+
NMR
NMR
8 (26)
8 (26)
Glu8
Glu8
His12/
Asn14
His12/
Asn14
10
12
(Iwatsuki et al.
2006
; Iwat-
suki et al.
2007
)
Propeptin
Propeptin2
c
19
17
0
0
N. E.
N. E.
9 (25)
9 (25)
Asp9
Asp9
n.i.
n.i.
10
8
(Esumi et al.
2002
; Kimura
et al.
2007
)
RES-701-1
RES-701-3
16
16
0
0
NMR
N.E./Char
9 (25)
9 (25)
Asp9
Asp9
n.i.
7
7
(Morishita et al.
1994
;
Yamasaki et al.
1994
;
Ogawa et al.
1995
; Yano
et al.
1995
; Katahira
et al.
1996
)
SRO15-2005
16
2+
N.E.
9 (29)
Glu9
n.i.
7
(Kersten et al.
2011
)
Sungsanpin
15
0
NMR
8 (25)
Asp8
Leu12 Ser13
/
Trp14
7
(Um et al.
2013
)
Search WWH ::
Custom Search