DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance - DNA Repair in Cancer Therapy - page 178

2. Vilenchik MM, Knidson AG. Endogenous DNA double-strand
breaks: production, fidelity of repair, induction of cancer. Proc
Natl Acad Sci USA 2003; 100 :12871 e 6.
3. Lieber MR, Gu J, Lu H, Shimazaki N, Tsai AG. Nonhomologous
DNA end joining (NHEJ) and chromosomal translocations in
humans. Subcell Biochem 2010; 50 :279 e 96.
4. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in
mammalian organs. Physiol Rev 1979; 59 :527 e 605.
5. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis
2000; 21 :361 e 70.
6. von Sonntag C. Free-Radical-Induced DNA Damage and Its Repair: A
Chemical Perspective . Berline: Springer. p. 2006.
7. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free
radicals, metals and antioxidants in oxidative stress-induced
cancer. Chem Biol Interact 2006; 160 :1 e 40.
8. Brenner DJ, Ward JF. Constraints on energy deposition and target
size of multiply damaged sites associated with DNA double-
strand breaks. Int J Radiat Biol 1992; 61 :737 e 48.
9. Goodhead DT. Initial events in the cellular effects of ionizing
radiations: clustered damage in DNA. Int J Radiat Biol 1994;
65 :7 e 17.
10. Sutherland BM, Bennett PV, Sidorkina O, Laval J. Clustered DNA
damages induced in isolated DNA and in human cells by low
doses of

24. Povirk LF. DNA damage and mutagenesis by radiomimetic
DNA-cleaving agents: bleomycin, neocarzinostatin and other
enediynes. Mutat Res 1996; 355 :71 e 89.
25. Kopp HG, Kuczyk M, Classen J, et al. Advances in the treatment
of testicular cancer. Drugs 2006; 66 :641 e 59.
26. Bartlett NL. Modern treatment of Hodgkin lymphoma. Curr Opin
Hematol 2008; 15 :408 e 14.
27. Linnert M, Gehl J. Bleomycin treatment of brain tumors: an
evaluation. Anticancer Drugs 2009; 20 :157 e 64.
28. Bennett RA, Swerdlow PS, Povirk LF. Spontaneous cleavage of
bleomycin-induced abasic sites in chromatin and their mutage-
nicity in mammalian shuttle vectors. Biochemistry 1993; 32 :
3188 e 95.
29. Wang P, Zhou RH, Zou Y, Jackson-Cook CK, Povirk LF. Highly
conservative reciprocal translocations formed by apparent
joining of exchanged DNA double-strand break ends. Proc Natl
Acad Sci USA 1997; 94 :12018 e 23.
30. Gredicak M, Jeric I. Enediyne compounds e new promises in
anticancer therapy. Acta Pharm 2007; 57 :133 e 50.
31. Liang ZX. Complexity and simplicity in the biosynthesis of ene-
diyne natural products. Nat Prod Rep 2010; 27 :499 e 528.
32. Dedon PC, Jiang ZW, Goldberg IH. Neocarzinostatin-mediated
DNA damage in a model AGT.ACT site: mechanistic studies of
thiol-sensitive partitioning of C4' DNA damage products.
Biochemistry 1992; 31 :1917 e 27.
33. Dedon PC, Salzberg AA, Xu J. Exclusive production of bistranded
DNA damage by calicheamicin. Biochemistry 1993; 32 :3617 e 22.
34. Zein N, Sinha AM, McGahren WJ, Ellestad GA. Calicheamicin
gamma 1I: an antitumor antibiotic that cleaves double-stranded
DNA site specifically. Science 1988; 240 :1198 e 201.
35. Hangeland JJ, De Voss JJ, Heath JA, et al. Specific abstraction of
the 5 0 (S) and 4 0 -deoxyribosyl hydrogen atoms from DNA by
calicheamicin g 1 I . J Am Chem Soc 1992; 114 :9200 e 2.
36. Maeda H. SMANCS and polymer-conjugated macromolecular
drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev
2001; 46 :169 e 85.
37. Damle NK, Frost P. Antibody-targeted chemotherapy with
immunoconjugates of calicheamicin. Curr Opin Pharmacol 2003; 3 :
386 e 90.
38. Takeshita A, Yamakage N, Shinjo K, et al. CMC-544 (inotuzumab
ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin,
alters the levels of target molecules of malignant B-cells. Leukemia
2009; 23 :1329 e 36.
39. Champoux JJ. DNA topoisomerases: structure, function, mecha-
nism. Annu Rev Biochem 2001; 70 :369 e 413.
40. Koster DA, Crut A, Shuman S, Bjornsti MA, Dekker NH. Cellular
strategies for regulating DNA supercoiling: a single-molecule
perspective. Cell 2010; 142 :519 e 30.
41. Pommier Y, Pourquier P, Fan Y, Strumberg D. Mechanism of
action of eukaryotic DNA topoisomerase I and drugs targeted to
the enzyme. Biochim Biophys Acta 1998; 1400 :83 e 105.
42. Pourquier P, Pommier Y. Topoisomerase I-mediated DNA
damage. Adv Cancer Res 2001; 80 :189 e 216.
43. Pourquier P, Pilon AA, Kohlhagen G, Mazumder A, Sharma A,
Pommier Y. Trapping of mammalian topoisomerase I and
recombinations induced by damaged DNA containing nicks or
gaps. Importance of DNA end phosphorylation and camptothe-
cin effects. J Biol Chem 1997; 272 :26441 e 7.
44. Schoeffler AJ, Berger JM. Recent advances in understanding
structure-function relationships in the type II

ionizing radiation. Proc Natl Acad Sci USA 2000;

97 :103 e 8.
11. Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational
approach for determining the spectrum of DNA damage induced
by ionizing radiation. Radiat Res 2001; 156 :577 e 83.
12. Weinfeld M, Rasouli-Nia A, Chaudhry MA, Britten RA. Response
of base excision repair enzymes to complex DNA lesions. Radiat
Res 2001; 156 :584 e 9.
13. Sage E, Harrison L. Clustered DNA lesion repair in eukaryotes:
relevance to mutagenesis and cell survival. Mutat Res 2010.
December 24 [Epub ahead of print].
14. Sczepanski JT, Wong RS, McKnight JN, Bowman GD,
Greenberg MM. Rapid DNA-protein cross-linking and strand
scission by an abasic site in a nucleosome core particle. Proc Natl
Acad Sci USA 2010; 107 :22475 e 80.
15. Kuzminov A. Single-strand interruptions in replicating chromo-
somes cause double-strand breaks. Proc Natl Acad Sci USA
2001; 98 :8241 e 6.
16. Saleh-Gohari N, Bryant HE, Schultz N, Parker KM, Cassel TN,
Helleday T. Spontaneous homologous recombination is induced
by collapsed replication forks that are caused by endogenous
DNA single-strand breaks. Mol Cell Biol 2005; 25 :7158 e 69.
17. Branzei D, Foiani M. The DNA damage response during DNA
replication. Curr Opin Cell Biol 2005; 17 :568 e 75.
18. Cortes-Ledesma F, Aguilera A. Double-strand breaks arising by
replication through a nick are repaired by cohesin-dependent
sister-chromatid exchange. EMBO Rep 2006; 7 :919 e 26.
19. Henner WD, Rodriguez LO, Hecht SM, Haseltine WA. Gamma
ray induced deoxyribonucleic acid strand breaks 3 0 glycolate

termini. J Biol Chem 1983; 258 :711 e 3.
20. Dedon PC. The chemical toxicology of 2-deoxyribose oxidation in
DNA. Chem Res Toxicol 2008; 21 :206 e 19.
21. Buchko GW, Weinfeld M. Influence of nitrogen, oxygen, nitro-
imidazole radiosensitizers on DNA damage induced by ionizing
radiation. Biochemistry 1993; 32 :2186 e 93.
22. Coquerelle T, Bopp A, Kessler B, Hagen U. Strand breaks and 5 0
end-groups in DNA of irradiated thymocytes. Int J Radiat Biol
Relat Stud Phys Chem Med 1973; 24 :397 e 404.
23. Lennartz M, Coquerelle T, Bopp A, Hagen U. Oxygen e effect on
strand breaks and specific end-groups in DNA of irradiated
thymocytes.

topoisomerase

mechanism. Biochem Soc Trans 2005; 33 :1465 e 70.
45. Wilstermann AM, Osheroff N. Base excision repair intermediates
as topoisomerase II poisons. J Biol Chem 2001; 276 :46290 e 6.
46. McClendon AK, Osheroff N. DNA topoisomerase II, genotoxicity,
cancer. Mutat Res 2007; 623 :83 e 97.

Int J Radiat Biol Relat Stud Phys Chem Med

1975; 27 :577 e 87.