Biomedical Engineering Reference
In-Depth Information
TABLE 1.2 (
continued
)
Control of Physico-Chemical Properties by Surface Functionalization
Property,
Method/Unit
Iso-electric point,
electrophoretic
mobility/pH
<1
4
7.2
<1
3.5
<1
7
>10
7.1
2.5
3.6
4.2
2
6.5
6.7
9.6
3.3
8.2
Zeta-potential at
pH 7.4/mV
−39
−26
0
−42.9
−39
−39
−7.8
3.9
−0.5
−20
−7
−7
−45
−20
−17
20
−39
5
Surface reactivity,
ESR/relative to
D
2
O
4/p-f s:
0.88
1/p-f s: 3.4
1/p-f s: 1.1
2.2/p-f s: 1.2
n.d.
1/p-f s: 2
1.5/
1/
0.54/p-f s:
5.7
8.0/
45/p-f
s: 1
72/
n.m.
2.7
0.82
22
2
2.3
Surface ROS
generation,
ESR/relative to
D
2
O
11/p-f s:
6.3
11/p-f s: 13
21/p-f s: 5.2
19/p-f s: 5
n.d.
3.6/p-f s: 1.5
1.7/
3.5/
0.94/p-f s:
1.3
0.5/
0.4/p-f
s: 1
0.48/
n.m.
1.9
3
12
2
1.3
Dispersibility indicated by AAN, average agglomeration number (ECHA 2012) = ratio of particle size in medium to BET-derived primary particle size. AUC, area under the curve; FCS, DMEM with 10% FCS; DLS, dynamic light scattering; ESR,
electron spin resonance; ROS, reactive oxygen species; SEM, scanning electron microscopy; TEM, transmission electron microscopy; TOD, trioxadecanoic acid; p-f s, particle-free supernatant; XRD, X-ray diffraction analysis; XPS, X-ray photoelec-
tron spectroscopy (Hellack et al. 2013).
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