Melatonin,Sleep And Insomnia

A Novel Disease Condition Presenting with Insomnia and Hypersomnia Asynchronization Part 2

Melatonergic System Melatonin not only regulates the circadian phase [75], but also acts as a hypnotic, is an effective free-radical scavenger and antioxidant, and directly induces gonadotropin-inhibitory hormone expression [76]. Interestingly, bright light during nighttime decreases melatonin secretion [77]. The existence of immunoreactivity against melatonin was demonstrated in the bacterium Rhodospirillum rubrum, one of the […]

A Novel Disease Condition Presenting with Insomnia and Hypersomnia Asynchronization Part 3

Potential Therapeutic Approaches Basic Principles For synchronization of the biological clock to a 24-hour cycle, exposure to morning light and avoidance of nocturnal light are essential. Therefore, lack of these two behaviors will result in asynchronization. Moreover, light-induced adrenal gene expression and corticosterone release have been demonstrated [136]. Under normal conditions, steroid secretion is greatest […]

Aggression in Older Adult Populations Part 1

Abstract In 2005, a report from the United Nations Populations Division noted that the number of individuals aged 60 years and older is expected to nearly triple, increasing from 672 million in 2005 to almost 1.9 billion by 2050. Currently the elderly population in developed countries has surpassed the number of individuals under the age […]

Aggression in Older Adult Populations Part 2

Aggression in Elderly Patients with Dementia Dementia is a brain disorder which manifests with clinical deficits in two or more areas of cognition which are of enough magnitude to significantly affect basic and necessary activities of daily living. Impairments typically present with memory loss and difficulties with executive function, judgment, insight, abstract thinking, visualspatial ability […]

The Impact of Cultural Changes on the Relationship between Senior Sleep Disturbance and Body Mass Index among Older Adults in Two Asian Societies Part 1

Abstract Population aging has materialized as an innovative demographic inclination with imperative insinuation for government programs, public health and education, and family restructuring. Among such changes, insomnia, snoring and sleep apnea, in conjunction with sleep hygiene have been usually ignored. Changes in sleep are part of the ageing process. Nocturnal total sleep time can become […]

The Impact of Cultural Changes on the Relationship between Senior Sleep Disturbance and Body Mass Index among Older Adults in Two Asian Societies Part 2

The Taiwanese Census Data Taiwan has been excluded from the United Nations and its related organizations since 1971. Taiwan has not been privy to the health related work of the World Health Organization (WHO). There is no Taiwanese census data available from WHO file. The Taiwanese National Health and Nutritional Survey for the period from […]

The Impact of Cultural Changes on the Relationship between Senior Sleep Disturbance and Body Mass Index among Older Adults in Two Asian Societies Part 3

Discussion Asian OSA Prevalence There is little information of the prevalence and severity of OSA in Asian snorers although OSA may not be uncommon in Asian patients. There is no information on snoring and OSA in Asian population either. Nevertheless, there is a single report on Singapore population, which is predominantly Chinese (Puvanendran et al […]

The Impact of Cultural Changes on the Relationship between Senior Sleep Disturbance and Body Mass Index among Older Adults in Two Asian Societies Part 4

Underweight The risk of being underweight (instead of normal weight) increases with age in the Philippines and Taiwan. In one Taiwanese Sleep Study (Tang 2007), 3.22% of the studied cohort was underweight. Another Taiwanese cohort of 778 cases was recruited in the multinational Global Lower Extremity Amputation (LEA) Study. Risk factors included age, sex, smoking, […]

A Novel Model Using Generalized Regression Neural Network (GRNN) for Estimating Sleep Apnea Index in the Elderly Suffering from Sleep Disturbance Part 1

Abstract Objective: The main objective of this paper is to present a novel model for classifying senior patients into different apnea/hypopnea index (AHI) categories based on their clinical variables. Methods and materials: The proposed model is a generalized regression neural network (GRNN). Three important variables were first selected from the original 30 clinical variables. The […]

A Novel Model Using Generalized Regression Neural Network (GRNN) for Estimating Sleep Apnea Index in the Elderly Suffering from Sleep Disturbance Part 2

Comparison with the Results of other Regression Models To demonstrate performance superiority of GRNN model proposed in this study, two other models, that is, linear regression and logistic regression, are developed for the same data and the results are compared and shown in Tables 5a and 5b for the training and testing sets, respectively. From […]

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